I’ve got some design considerations about creating Volumes in storage which supposed to be used by virtualization infrastructure (VMware 5.1) as datastore; I ended up reading this great article by Michael Webster which saved my day and I would like to share:
The Case for Larger Than 2TB Virtual Disks and The Gotcha with VMFS
Overall, it seems that VMware vSphere 5.5 has good advantages and improvements over 5.1.