Since VMware vCenter uses ports 80, 443 to provide access to management console (for both vSphere Client and Web Console), it’s important to secure these ports. Having said that, it can be limiting access to specific IP addresses in your internal network. If there is no firewall between your internal network and Cloud infrastructure, at least configure Firewall in Windows machine (if vCenter is installed on Windows) to restrict access.

Also, for a complete list of tasks to harden vCenter Security, you can see Security Advisories, Guides document from VMware.